Hosting Neurotoxicity in Polyglutamine Disease

نویسندگان

  • Nan Liu
  • Nancy M. Bonini
چکیده

Polyglutamine diseases are caused by an expanded glutamine domain thought to confer a toxic activity onto the respective disease proteins. In this issue, propose that toxicity of the polyglutamine protein Ataxin-1 may not be due to abberant protein interactions mediated by the polyglutamine expansion. Instead, they suggest that toxicity is solely due to interactions of Ataxin-1 with its normal binding partners.

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عنوان ژورنال:
  • Cell

دوره 127  شماره 

صفحات  -

تاریخ انتشار 2006